CORE Nutritionals - OMEGA - High Purity Fish Oil - 120 Softgels - Exp 12/2024 Description: CORE OMEGA
When it comes to dietary supplement purchases, consumers are
discerning and exact: the dose, form, extract, standardization and more must
precisely conform to their standards. The brand matters, the compounds matter,
and how those compounds are produced matters.
But when it comes to the basic supplements, the staples,
most people have the attitude, “It’s all the same.” They travel to their local
supplement store, browse quickly online, or grab whatever’s on the grocery
store shelves and call it a day. Why? Shouldn’t the staples, something you are
placing in your body everyday, be purchased with as much exactitude as the
exotic stuff? And more importantly, shouldn’t they be produced with as much
care and attention to specifics?
At Core, we think they should – and that’s why we’ve
released Core OMEGA. Core OMEGA is a fish oil supplement, the Core way. What
does that mean? Well, it means carefully selecting a fish oil manufacturer for
our product that produces its fish oils under the all important nitrogen
barrier – a manufacturing technique that greatly reduces the chance for
oxidation, significantly expands the product’s effective shelf life, and all
but eliminates any “fish” taste or smell from the oil. It also means ensuring
that our fish oil product contains proper levels of the all-important DHA and
EPA, with 480mg and 720mg respectively in each serving. Lastly, it means using
the purified triglyceride form, rather than the more common ethyl esters.*
In total, this is not just another fish oil product – it is
the fish oil product. SCIENTIFIC BREAKDOWN
Nitrogen Barrier Production
Oil derived from marine animals – commonly referred to as
“fish oils” – are widely consumed for the high amounts of polyunsaturated fatty
acids (such as DHA and EPA) that they contain and the potential health benefits
that these fatty acids confer. Unfortunately, polyunsaturated fatty acids are
notoriously unstable: they are composed of double-bonds between carbon atoms, a
chemical structure that is notoriously susceptible to oxidation. (Oxidation is
the process of producing oxygen species as a consequence of a compound’s
exposure to oxygen.)
For fish oil, oxidation has a number of deleterious effects
– principally, the production of hydroperoxides (the first step in oxidation)
and secondary oxygen products not only produce the rancid, “fish” smell
typically associated with lower quality fish oil products; but perhaps more
importantly, in breaking the double bond structure of the fish oil, these
oxygen species degrade the integrity of the product and thus reduce their
potential health benefits. The oxidation degradation is unfortunately
widespread. One study found that 50% of 171 fish oil supplements in Canada
exceeded the limits for at least one measure of oxidation, and 39% exceeded the
international voluntary safety recommendations for total oxidation (TOTOX
value).” Another study found that approximately 29% of fish oil supplements in
the United States similarly exceeded recommended values.
Luckily, research has shown that reducing the exposure of
fish oils to oxygen and environmental factors (humidity and temperature
fluctuations) during the production process can significantly mitigate
oxidation. One of the most effective ways to reduce oxygen exposure is to
blanket the oil, as soon as its processed and produced, in an inert gas such as
argon or nitrogen – thereby preventing the fish oil from coming into contact
with oxygen at all. While exact values will vary by product, research has shown
that both primary oxidation (the production of hydroperoxides, measured in
peroxide value, PV) and secondary oxidation (measured in TOTOX (total oxidation
value) and a-nsidine values) are vastly reduced through a nitrogen blanket or
barrier.
In sum, producing fish oils under a nitrogen blanket or
barrier not only reduces the rancid smell typically associated with fish oil
products; but vastly extends their shelf life and integrity.
TRIGLYCERIDES VS ETHYL ESTER FORMS
We have established that how fish oils are produced may
impact their viability as a dietary supplement. But the production process is
not the only salient factor in fish oil efficacy and viability – the form that
a fish oil takes is paramount, as well. Specifically, the differences between triglycerides
and ethyl esters may be formative in how fish oils are absorbed and confer
their potential health benefits.
First, a little primer on what triglycerides and ethyl
esters are. Triglycerides are a molecular form common to almost all plant and animal
species: a glycerol backbone with three fatty acids (in the case of fish oils,
EPA and DHA) attached to them. For example, the “stuff” of human adipose (fat)
tissue is triglycerides. Ethyl Esters, on the other hand, lack a glycerol
backbone – they are a single fatty acid molecule attached to an ethanol
molecule. Unlike triglycerides, ethyl esters are not a natural molecular form
and formed solely through chemical synthesis.
While the difference between triglycerides and ethyl esters
as applied to fish oil may seem academic, it in fact has profound implications
for the absorption and bioavailability of these oils. In very condensed form,
the issue is twofold: how the fish oil is taken up into the bloodstream
(absorption) and how it is made available to cells once that has occurred
(bioavailability). In both contexts, there is evidence that triglycerides are
superior to the ethyl ester form.
For bioavailability, the issue is how the small intestine
breaks down each form of fish oil. As a natural product, our bodies are
intrinsically capable of breaking down triglycerides via bile salts and
pancreatic lipase. Once ingested, pancreatic lipase and bile salts are
released, and in the small intestine, the triglyceride is broken down into
so-called emulsion droplets – which can then easily be broken up, detaching the
two fatty acid molecules from the glycerol backbone. Not so with ethyl esters.
Not only is pancreatic lipase (by some estimates) 50% less effective in
breaking down ethyl esters; but once digested, ethyl esters must be converted
into triglycerides through the liberated fatty acids attaching to a glycerol
molecule. Essentially, your body must reverse the entire metabolism of ethyl
esters, then go through the normal triglyceride metabolism.
The biochemical differences between triglycerides and ethyl
esters have been demonstrated in trials examining bioavailability and
absorption efficiency. One study found that, when ingested in triglyceride
form, EPA and DHA levels were 340% and 271%, respectively, as compared to the
ethyl ester form. Additional research has found a 25% increase in plasma EPA
and DHA levels over a six month period; that ethyl esters are “poorly absorbed”
by man; and that triglyceride form fish oils suffer less oxidation (on shelf) than
the ethyl ester form.